A report published by VoteWatchEurope on 19 April 2016, provides a gloom outlook for the European Union, in case the referendum on EU-UK relations on 23 June 2016 would indeed lead to a negative vote. Following earlier remarks by Nicola Sturgeon, the Prime Minister of Scotland, that the country would hold another referendum on Scottish independence if the UK would leave, the report speculates on further domino effects. Traditional allies of the UK, such as Sweden and Denmark, but also Poland and Hungary could reconsider their memberships as well. A poll has found that a majority of Swedes would want to leave the EU in case the UK would leave. A so called ''Brexit'' could therefore unleash another crisis, and potentially lead to more disintegration of the European Union.

On 19 April 2016, the Dutch Parliament rejected a motion initiated by the Socialist party that called for the immediate rejection of a law to ratify the Association Agreement of the EU with Ukraine. It follows the earlier negative result of the non-binding referendum, that was held in the Netherlands. The motion was rejected by a narrow majority, 75 against and 71 votes in favour. Earlier the week before, it was decided that the Dutch Government would be given time until the summer to consult with other EU partners on what to do with the agreement, or at least until after the referendum by the UK on whether to leave the EU on 23 June 2016. In the meanwhile, EU-Ukraine relations are further fostered. Although unrelated to the agreement, visa liberalisation has recently been proposed by the European Commission.

On 19 April 2016, US primaries were held in the state of New York. As expected and confirmed in recent polls, both Donald Trump and Hillary Clinton secured their victories. Donald Trump won by an astonishing percentage of 60,4%, leaving John Kasich and Ted Cruz far behind him with 25,1% and 14,5% respectively. Hillary Clinton, on the other hand, secured a victory of 58%, compared to 42% for Bernie Sanders.

Recent developments in the case of the "Panama Papers" leak brought to a vote of no confidence aimed to replace the Malta's government. On April 18, a debate in the Parliament led to the opposition bringing forward a motion of no confidence. Prime Minister Joseph Muscat decided not to demand the resignation of Konrad Mizzi, the minister of energy and health, and that of Keith Schembri, the chief of staff, both accused of owning companies in Panama and a trust in New Zealand. The government won and the motion failed. In the vote, 69 MPs participated; 50 of them asked to speak, and the opposition lost with 31 votes in favor of no confidence and 38 votes against. Prime Minister Muscat responded by saying he will not make any decision before the completion of the investigation on the matter. By that he squelched the voices calling for said resignations.

The Brazilian Lower House of Congress approved the impeachment procedure of the President Dilma Rousseff on Sunday night 17 April. A two-thirds majority of votes was required in the Chamber of Deputies, composed of 513 members, in order to approve the impeachment motion. The final vote was 367 for impeachment and 137 against. Due to this decision, the impeachment measure will now move directly to the Senate, where only a simple majority is needed to decide on whether to hold a trial which could force Rousseff to step down. If the majority approves it, the Brazilian first female President will be forced to resign for at least 180 days in order to prepare to her trial which will be crucial for her political career. Rousseff is accused of breaking budget laws by manipulating the government account back in 2014.

Following the "Brexit" debate, Nicola Sturgeon, the leader of the Scottish National Party, stated that she will not campaign alongside Prime Minister David Cameron and instead, her political agenda will promote the prospect of the new referendum on Scottish independence in case the UK will leave the EU "against the Scottish will". In the recent polls, 59% of Scots expressed their will to remain in the EU, which is in contrast with the majority’s opinion in the UK.